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xy='[{\"x\":\"22\",\"y\":\"1287\"},{\"x\":\"1443\",\"y\":\"1287\"},{\"x\":\"1443\",\"y\":\"2045\"},{\"x\":\"22\",\"y\":\"2045\"}]' coords='' alt='别只盯着皮损，银屑病还会损伤关节' href='\/html\/xmwb\/2026-07-06\/14\/242195.html' title='别只盯着皮损，银屑病还会损伤关节'>\r\n \r\n \r\n <area shape='polygon' xy='[{\"x\":\"22\",\"y\":\"364\"},{\"x\":\"1444\",\"y\":\"364\"},{\"x\":\"1444\",\"y\":\"1217\"},{\"x\":\"22\",\"y\":\"1217\"}]' coords='' alt='中西医结合守护胰腺健康' href='\/html\/xmwb\/2026-07-06\/14\/242194.html' title='中西医结合守护胰腺健康'>\r\n <\/map>\r\n <\/div>\r\n <\/div>\r\n \r\n <div class=\"dzb-enter-info-box dzb-heng-info-box layui-col-xs7\">\r\n <div class=\"dzb-enter-banmian-box\">\r\n <div class=\"dzb-banmian-logo-box\">\r\n <img src=\"\/dianzibao\/images\/banmian_logo.png\" alt=\"\" class=\"dzb-banmian-logo\" width=\"120\" height=\"39\">\r\n <\/div>\r\n <span class=\"dzb-banmian-title\">第14版：康健园<\/span>\r\n <span class=\"dzb-banmian-date\">2026-07-06<\/span>\r\n <\/div>\r\n <div class=\"dzb-enter-desc-box dzb-enter-heng-desc-box\">\r\n <span class=\"dzb-special-title-box\"><\/span>\r\n <h2 class=\"dzb-title-box\">50岁以上男性每年必查PSA<\/h2>\r\n <span class=\"dzb-sub-title-box\"><\/span>\r\n \r\n <p class=\"dzb-desc-box\"> 对于中老年男性来说，前列腺癌是最需要重视的疾病之一。血清前列腺特异性抗原（PSA）不仅是早期发现前列腺癌的重要指标，更是初筛和预警指标。近日，上海交通大学医学院附属仁济医院泌尿外科主任潘家骅教授特别提及前列腺癌早期筛查的重要性和必要性，PSA应成为50岁以上男性每年体检的必查项目。<br\/><br\/> 我国前列腺癌患者初诊时分期偏晚的特点较为突出，约30%的患者初诊时已发生远处转移，另有30%至35%的患者为局部进展期。早期局限性前列腺癌的10年生存率可达98%，而晚期转移性患者在过去5年生存率仅为30%，即便在新型内分泌治疗普及后提升至60%左右，两者之间仍有明显差距。近期发表于《欧洲泌尿外科杂志》的一项纳入72万例患者的汇总分析显示，PSA筛查可显著提高10年和12年生存率，为筛查的临床价值提供了高级别证据。B超在前列腺肿瘤筛查中也有一定价值，能够观察前列腺大小、形态及低回声病灶，磁共振检查则在精确定位和肿瘤分期方面更具优势。<br\/><br\/> 目前尚无充分证据表明前列腺炎或良性前列腺增生会转化为前列腺癌，三者之间没有必然的因果关系。但前列腺炎和前列腺增生引起的排尿症状会干扰前列腺癌的早期发现，出现相关症状时仍需进行排查。反而是肥胖和高脂肪摄入与前列腺癌的发生发展有一定关联，高胆固醇水平在前列腺肿瘤的侵袭进展和耐药中扮演着重要角色。因此，中老年男性不仅要定期体检，更要保持健康的生活方式，适量运动，避免久坐，戒烟限酒，减少高热量高脂肪食物摄入，多吃新鲜的蔬菜水果，如番茄、西蓝花等。<br\/><br\/> 近十年来，前列腺癌的治疗进展迅速。早期局限性前列腺癌可通过根治性手术或放化疗实现治愈，机器人手术已使肿瘤切除更加精准、规范，患者的尿控和性功能保护均有明显改善。对于中晚期患者而言，新型内分泌治疗（二代雄激素受体抑制剂）如恩扎卢胺等药物延长了患者的生存期，转移性激素敏感性前列腺癌患者的中位总生存期能够超过5年。放射性核素药物177Lu-PSMA-617已于去年进入临床应用，为转移性去势抵抗性前列腺癌患者提供了新的治疗选择。曾有一名50多岁的患者初诊时已有肺转移和骨转移，经过基因检测等检查后，潘家骅教授团队为他制定并施行了早期三联治疗方案，目前患者已退休多年，生活状态良好，仍保持正常运动和旅游。<br\/><br\/> 潘家骅教授强调，晚期前列腺癌已进入慢病化管理时代，患者应积极配合疾病全程管理，每三个月复查PSA和睾酮，每半年进行一次影像学评估，同时患者应关注症状变化——部分肿瘤在治疗压力下可发生谱系转化，不再产生PSA，因此不能仅凭PSA水平判断病情。此外，老年患者常合并高血压、糖尿病等慢性病，选择内分泌治疗药物时需考虑合并用药情况，做到个体化施治。前列腺癌治疗的未来方向是微创化和个体化，通过精准的分子分型实现分层施治，有望改善预后。乔闳<br\/><br\/><\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n \r\n <div class=\"dzb-multi-btn-box\">\r\n <p class=\"dzb-multi-zoomOut dzb-multi-btn-hover\"><a href=\"javascript:;\"><img src=\"\/dianzibao\/images\/btn_A.png\"\n\n alt=\"\">放大<\/a><\/p>\n\n<p class=\"dzb-multi-zoomIn dzb-multi-btn-hover hide\"><a href=\"javascript:;\"><img src=\"\/dianzibao\/images\/btn_A.png\" alt=\"\">缩小<\/a>\n\n<\/p>\n\n<p class=\"dzb-multi-prev dzb-multi-btn-hover\"><a 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title=\"别只盯着皮损，银屑病还会损伤关节\">别只盯着皮损，银屑病还会损伤关节<\/a>\r\n <a href=\"\/html\/xmwb\/2026-07-06\/14\/242194.html\" title=\"中西医结合守护胰腺健康\">中西医结合守护胰腺健康<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n<\/li>\r\n \r\n\r\n \r\n <li class=\"dzb-enter-nav-li\">\r\n <a href=\"javascript:;\">目录<\/a>\r\n <div class=\"dzb-enter-nav-wrap hide\" style=\"width:auto;padding:10px;\">\r\n <div class=\"dzb-enter-opacity-box\"><\/div>\r\n <div class=\"dzb-enter-wrap dzb-enter-mulu-wrap\">\r\n <div style=\"min-height:435px;overflow:hidden\">\r\n <div class=\"dzb-enter-mulu-wrap-nav\">\r\n <a href='\/html\/xmwb\/2026-07-06\/1\/242143.html' title=\"第1版:一版要闻\">第1版:一版要闻<\/a>\r\n <\/div>\r\n <div class=\"dzb-enter-mulu-wrap-nav\">\r\n <a href='\/html\/xmwb\/2026-07-06\/2\/242151.html' title=\"第2版:要闻\">第2版:要闻<\/a>\r\n <\/div>\r\n <div class=\"dzb-enter-mulu-wrap-nav\">\r\n <a href='\/html\/xmwb\/2026-07-06\/3\/242155.html' title=\"第3版:上海新闻\">第3版:上海新闻<\/a>\r\n <\/div>\r\n <div class=\"dzb-enter-mulu-wrap-nav\">\r\n <a 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class=\"dzb-enter-desc-box dzb-enter-heng-desc-box\">\r\n <span class=\"dzb-special-title-box\"><\/span>\r\n <h2 class=\"dzb-title-box\">50岁以上男性每年必查PSA<\/h2>\r\n <span class=\"dzb-sub-title-box\"><\/span>\r\n \r\n <p class=\"dzb-desc-box\"> 对于中老年男性来说，前列腺癌是最需要重视的疾病之一。血清前列腺特异性抗原（PSA）不仅是早期发现前列腺癌的重要指标，更是初筛和预警指标。近日，上海交通大学医学院附属仁济医院泌尿外科主任潘家骅教授特别提及前列腺癌早期筛查的重要性和必要性，PSA应成为50岁以上男性每年体检的必查项目。<br\/><br\/> 我国前列腺癌患者初诊时分期偏晚的特点较为突出，约30%的患者初诊时已发生远处转移，另有30%至35%的患者为局部进展期。早期局限性前列腺癌的10年生存率可达98%，而晚期转移性患者在过去5年生存率仅为30%，即便在新型内分泌治疗普及后提升至60%左右，两者之间仍有明显差距。近期发表于《欧洲泌尿外科杂志》的一项纳入72万例患者的汇总分析显示，PSA筛查可显著提高10年和12年生存率，为筛查的临床价值提供了高级别证据。B超在前列腺肿瘤筛查中也有一定价值，能够观察前列腺大小、形态及低回声病灶，磁共振检查则在精确定位和肿瘤分期方面更具优势。<br\/><br\/> 目前尚无充分证据表明前列腺炎或良性前列腺增生会转化为前列腺癌，三者之间没有必然的因果关系。但前列腺炎和前列腺增生引起的排尿症状会干扰前列腺癌的早期发现，出现相关症状时仍需进行排查。反而是肥胖和高脂肪摄入与前列腺癌的发生发展有一定关联，高胆固醇水平在前列腺肿瘤的侵袭进展和耐药中扮演着重要角色。因此，中老年男性不仅要定期体检，更要保持健康的生活方式，适量运动，避免久坐，戒烟限酒，减少高热量高脂肪食物摄入，多吃新鲜的蔬菜水果，如番茄、西蓝花等。<br\/><br\/> 近十年来，前列腺癌的治疗进展迅速。早期局限性前列腺癌可通过根治性手术或放化疗实现治愈，机器人手术已使肿瘤切除更加精准、规范，患者的尿控和性功能保护均有明显改善。对于中晚期患者而言，新型内分泌治疗（二代雄激素受体抑制剂）如恩扎卢胺等药物延长了患者的生存期，转移性激素敏感性前列腺癌患者的中位总生存期能够超过5年。放射性核素药物177Lu-PSMA-617已于去年进入临床应用，为转移性去势抵抗性前列腺癌患者提供了新的治疗选择。曾有一名50多岁的患者初诊时已有肺转移和骨转移，经过基因检测等检查后，潘家骅教授团队为他制定并施行了早期三联治疗方案，目前患者已退休多年，生活状态良好，仍保持正常运动和旅游。<br\/><br\/> 潘家骅教授强调，晚期前列腺癌已进入慢病化管理时代，患者应积极配合疾病全程管理，每三个月复查PSA和睾酮，每半年进行一次影像学评估，同时患者应关注症状变化——部分肿瘤在治疗压力下可发生谱系转化，不再产生PSA，因此不能仅凭PSA水平判断病情。此外，老年患者常合并高血压、糖尿病等慢性病，选择内分泌治疗药物时需考虑合并用药情况，做到个体化施治。前列腺癌治疗的未来方向是微创化和个体化，通过精准的分子分型实现分层施治，有望改善预后。乔闳<br\/><br\/><\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n \r\n <div class=\"dzb-multi-btn-box\">\r\n <p class=\"dzb-multi-zoomOut dzb-multi-btn-hover\"><a href=\"javascript:;\"><img src=\"\/dianzibao\/images\/btn_A.png\"\n\n alt=\"\">放大<\/a><\/p>\n\n<p class=\"dzb-multi-zoomIn dzb-multi-btn-hover hide\"><a href=\"javascript:;\"><img src=\"\/dianzibao\/images\/btn_A.png\" alt=\"\">缩小<\/a>\n\n<\/p>\n\n<p class=\"dzb-multi-prev dzb-multi-btn-hover\"><a 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